Identification of Mediators of Cachexia and Inter-Organ Cross-Talk in Drosophila
Grant number: 1182847 | Funding period: 2020 - 2023
Completed
Abstract
Cachexia is a metabolic disorder that affects some 9 million people worldwide, and involves extreme weight- and muscle-loss. It is a disease driven by metabolic imbalance between tumours, muscle and fat. Here we use fruit flies to find out how specific mutations can drive cachexia, what factors are mediating the communication between tumour and other tissues, and watch cachexia occur in real time. For the first time, we can study how tumours and organs communicate.